MovDisordV3, Main, Exploration, bibRecord, 000417

Stem cells for cell replacement therapy: a therapeutic strategy for HD?

Identifieur interne : 000417 ( Main/Exploration ); précédent : 000416; suivant : 000418

Stem cells for cell replacement therapy: a therapeutic strategy for HD?

Auteurs : Anne Rosser [Royaume-Uni] ; Clive N. Svendsen

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.

RBID : pubmed:25216372

English descriptors

KwdEn :
- Animals, Cell- and Tissue-Based Therapy (methods), Humans, Huntington Disease (therapy), Stem Cells (physiology).
MESH :
- methods : Cell- and Tissue-Based Therapy.
- physiology : Stem Cells.
- therapy : Huntington Disease.
- Animals, Humans.

Abstract

Much interest has been expressed over the last couple of decades in the potential application of stem cells to medicine, both for research and diagnostic tools and as a source of donor cells for therapeutic purposes. Potential therapeutic applications include replacement of cells in many body organs where the capacity for intrinsic repair is limited, including the pancreas, heart, and brain. A key challenge is to generate the relevant donor cell types, and this is particularly challenging in the brain where the number of different neuronal subtypes is so great. Although dopamine neuron replacement in Parkinson's disease has been the focus of most clinical studies, great interest has been shown in this approach for other disorders, including Huntington's disease. Replacing complete neural circuits in the adult brain is clearly challenging, and there are many other complexities with regard to both donor cells and host. This article presents the pros and cons of taking a cell therapy approach in Huntington's disease. It considers the implantation both of cells that are already of the same neural subtype as those lost in the disease process (ie, primary fetal cells derived from the developing striatum) and those derived from stem cells, which require "directing" toward that phenotype.

DOI: 10.1002/mds.26026
PubMed: 25216372

Affiliations:

Royaume-Uni

Le document en format XML

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<author><name sortKey="Svendsen, Clive N" sort="Svendsen, Clive N" uniqKey="Svendsen C" first="Clive N" last="Svendsen">Clive N. Svendsen</name>
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<front><div type="abstract" xml:lang="en">Much interest has been expressed over the last couple of decades in the potential application of stem cells to medicine, both for research and diagnostic tools and as a source of donor cells for therapeutic purposes. Potential therapeutic applications include replacement of cells in many body organs where the capacity for intrinsic repair is limited, including the pancreas, heart, and brain. A key challenge is to generate the relevant donor cell types, and this is particularly challenging in the brain where the number of different neuronal subtypes is so great. Although dopamine neuron replacement in Parkinson's disease has been the focus of most clinical studies, great interest has been shown in this approach for other disorders, including Huntington's disease. Replacing complete neural circuits in the adult brain is clearly challenging, and there are many other complexities with regard to both donor cells and host. This article presents the pros and cons of taking a cell therapy approach in Huntington's disease. It considers the implantation both of cells that are already of the same neural subtype as those lost in the disease process (ie, primary fetal cells derived from the developing striatum) and those derived from stem cells, which require "directing" toward that phenotype.</div>
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Movement Disorders (revue)

Stem cells for cell replacement therapy: a therapeutic strategy for HD?

Stem cells for cell replacement therapy: a therapeutic strategy for HD?

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.